Caffeine is a powerful and very common alkaloid supplement used in ThermaZyne primarily to increase the body’s ability to lose weight quickly, boost energy and stimulate the brain into more activity with better clarity. It also fuels the body’s metabolism for increased fat burning qualities. This allows users to have more stamina for exercise and more focus for weight loss initiatives. Caffeine anhydrous is found naturally in many different beans and plants and works successfully as a stimulating supplement for those needing increased energy, focus, and alertness. When taken as a supplement for health or weight loss reasons, caffeine anhydrous should not be combined with other traditional forms of caffeine, such as soft drinks, energy drinks, coffee, or tea, because the supplement form is concentrated and powerful in itself.

Citrus Aurantium, More commonly called "bitter orange", which is taken from unripe oranges. Research shows that citrus aurantium can increase the metabolic rate without affecting heart rate or blood pressure, breaks down fat, burns calories and may act as an appetite suppressant.

Synthetic Guggulsteroneswere first intended for use as a drug and is now used as a weight loss product and weight management product with the possibility of some side effects. More studies need to be done on this.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.