Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Caffeine is a stimulant that is used to stay awake and it gives mental alertness from fatigue. This is used as an adjunct for pain relief and also as energy accelerates. Caffeine is a non-prescription drug easily available as over the counter medication and comes in combination to acquire relief from headache and pain. Caffeine increases the mental alertness by offering the required energy for exercise training and weight loss. Caffeine cannot be considered as a mere stimulant as it reaches deep into muscles and provides power that is long lasting. Caffeine taken before any work out is also great as it fights the fatigue and keeps the person ready for the workout. Dieters also find caffeine as the solution as they feel sluggish. This is a no-calorie stimulant and does its job effectively and quickly. Caffeine anhydrous is found even in one or two coffee cups. However, this limitation is recommended as excess caffeine may result in irritability, rapid heart beat, nervousness and sleeplessness.

Guggulsterone- Commiphora wightii, or the so called Guggul tree is a flowering shrub or rather a small tree which can grow up to a size of 4 meters. Once very common in India, it is now there listed as endangered, but not in northern Africa or elsewhere in central Asia. It was very popular in the Indian Ayurvedic medicine, but also currently in the western medicine for treating of heart problems. The hydrocarbon secretion of Guggul contains a plant sterol, guggulsterone, which in the human body seems to act as an antagonist to the farnesoid X receptor. Furthermore, guggulsterone is active in increasing the natural thyroid production. This in turn stimulates the metabolism and may raise the body temperature, burning stored excess fat.

Synephrine, a semi-selective sympathomimetic, is used to stimulate the adrenaline system. Also known as ‘zhi shi’, green orange or bitter orange; it is a chief, active constituent found in the fruit belonging to the plant, Citrus aurantium. Synephrine is not only similar to ephedra in its chemical composition but also serves the same benefits as caffeine or ephedrine. However, it mildly stimulates the fat metabolism without causing any of the side effects associated with ephedra based products. The best advantage of using Synephrine is that it increases the metabolic rate without affecting the hemodynamics. Thus, it is comparatively much safer than ephedra. Since Synephrine promotes weight loss and supports thermogenesis, Synephrine supplements are an ideal solution for dieters and weight watchers. The total intake should be between 2 to 10 mg. per day.

Yohimbe- Basically a tree bark, Yohimbe is rich in pharmacologically active chemicals. It is commonly found in products developed for body building and enhancing male performance. The use of Yohimbe causes serious side effects too that include renal failure, seizures and in very rare cases, even death. Individuals suffering from low blood pressure, heart disease, liver or kidney disease, and diabetes should refrain from using any kind of Yohimbe supplements. Taking larger doses of Yohimbe can cause weakness, stomach disorders, fatigue, and nervous stimulation followed by paralysis. It is therefore important to avoid self-medication. Sometimes, side effects may arise even if small amounts of this supplement are taken, especially for prolonged periods. If you are already taking drugs for treating some health condition, it is best to avoid this supplement.